The Narcotics Program focuses on Postal Service employees involved in possessing or using illegal drugs as well as facilitating distribution of them. When the OIG receives allegations or develops information about any such instance, special agents investigate using a variety of means and techniques.

After an investigation concludes, the OIG will, if warranted, submit the case for criminal prosecution. Defendants face the possibility of not only losing their jobs, but also of going to jail and being ordered to pay restitution. Additionally, the OIG may refer the case to USPS management for appropriate administrative action.